اثرات متقابل ژن- ماده مغذی در بروز سرطان؛ یک مطالعه مروری سیستماتیک

--Advances in molecular biology over the past decades have contributed to a profound understanding of the function of genes in the development of diseases. The environment and nutritional factors interact with the genetic background of subject results in development of various diseases including cancer, cardiovascular disease and degenerative nervous disorders. However, the exact mechanisms of gene-nutrient interaction have not yet been fully elucidated. Understanding the interactions of gene-nutrients requires tools for studying nutrigenomics and phenotype characteristics. In order to revewing studies about the interactions of the gene-nutrient in cancer, I was searched in valuable databases such as PabMed, Science Direct, Medline and Scopus for the period of 2000-2015. The results of the study showed that many micronutrients and vitamins are important in the mechanisms of DNA metylation regulation. Understanding the pattern of DNA methylation through its interaction with nutrients not only addresses the pathophysiology of the disease, but also identifies endangered individuals with the goal of nutritional interventions and their health. Advances in molecular biology over the past decades have contributed to a profound understanding of the function of genes in the development of diseases. The environment and nutritional factors interact with the genetic background of subject results in development of various diseases including cancer, cardiovascular disease and degenerative nervous disorders. However, the exact mechanisms of gene-nutrient interaction have not yet been fully elucidated. Understanding the interactions of gene-nutrients requires tools for studying nutrigenomics and phenotype characteristics. In order to revewing studies about the interactions of the gene-nutrient in cancer, I was searched in valuable databases such as PabMed, Science Direct, Medline and Scopus for the period of 2000-2015. The results of the study showed that many micronutrients and vitamins are important in the mechanisms of DNA metylation regulation. Understanding the pattern of DNA methylation through its interaction with nutrients not only addresses the pathophysiology of the disease, but also identifies endangered individuals with the goal of nutritional interventions and their health. &nbsp; <!--{cke_protected}